Hats off to 20S proteasome substrate discovery

Taylor R Church; Anna Brennan; Seth S Margolis

doi:10.1038/s44320-024-00028-7

Molecular Systems Biology (Mar 2024)

Hats off to 20S proteasome substrate discovery

Taylor R Church,
Anna Brennan,
Seth S Margolis

Affiliations

Taylor R Church: Department of Biological Chemistry, The Johns Hopkins University School of Medicine
Anna Brennan: Department of Biological Chemistry, The Johns Hopkins University School of Medicine
Seth S Margolis: Department of Biological Chemistry, The Johns Hopkins University School of Medicine

DOI: https://doi.org/10.1038/s44320-024-00028-7
Journal volume & issue: Vol. 20, no. 4
pp. 293 – 295

Abstract

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Uncapped free 20S proteasomes are abundant and active in cells, and yet their degraded intracellular protein substrates have remained underexplored. In their recent study, Sharon and colleagues (Pepelnjak et al, 2024) developed an advanced proteomics method (PiP-MS) to comprehensively explore 20S proteasome substrates in the human proteome.

Published in Molecular Systems Biology

ISSN: 1744-4292 (Online)
Publisher: Springer Nature
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General); Medicine: Medicine (General)
Website: https://www.embopress.org/journal/17444292

About the journal