Department of Psychiatry, University of California San Francisco, San Francisco, United States; Neuroscience Graduate Program, University of California San Francisco, San Francisco, United States
Jin Chen
Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, United States; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, United States
Siavash Fazel Darbandi
Department of Psychiatry, University of California San Francisco, San Francisco, United States
Frances S Cho
Neuroscience Graduate Program, University of California San Francisco, San Francisco, United States; Department of Neurology, University of California San Francisco, San Francisco, United States; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, United States
Jiapei Chen
Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, United States; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, United States
Susan Lindtner
Department of Psychiatry, University of California San Francisco, San Francisco, United States
Julia S Chu
Department of Neurology, University of California San Francisco, San Francisco, United States
Jeanne T Paz
Neuroscience Graduate Program, University of California San Francisco, San Francisco, United States; Department of Neurology, University of California San Francisco, San Francisco, United States; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, United States; The Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, United States
Daniel Vogt
Department of Pediatrics and Human Development, Michigan State University, Grand Rapids, United States
Mercedes F Paredes
Neuroscience Graduate Program, University of California San Francisco, San Francisco, United States; Department of Neurology, University of California San Francisco, San Francisco, United States; The Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, United States
Department of Psychiatry, University of California San Francisco, San Francisco, United States; The Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, United States
Maf (c-Maf) and Mafb transcription factors (TFs) have compensatory roles in repressing somatostatin (SST+) interneuron (IN) production in medial ganglionic eminence (MGE) secondary progenitors in mice. Maf and Mafb conditional deletion (cDKO) decreases the survival of MGE-derived cortical interneurons (CINs) and changes their physiological properties. Herein, we show that (1) Mef2c and Snap25 are positively regulated by Maf and Mafb to drive IN morphological maturation; (2) Maf and Mafb promote Mef2c expression which specifies parvalbumin (PV+) INs; (3) Elmo1, Igfbp4 and Mef2c are candidate markers of immature PV+ hippocampal INs (HIN). Furthermore, Maf/Mafb neonatal cDKOs have decreased CINs and increased HINs, that express Pnoc, an HIN specific marker. Our findings not only elucidate key gene targets of Maf and Mafb that control IN development, but also identify for the first time TFs that differentially regulate CIN vs. HIN production.
