Nature Communications (Sep 2019)

Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

  • Bojana Lucic,
  • Heng-Chang Chen,
  • Maja Kuzman,
  • Eduard Zorita,
  • Julia Wegner,
  • Vera Minneker,
  • Wei Wang,
  • Raffaele Fronza,
  • Stefanie Laufs,
  • Manfred Schmidt,
  • Ralph Stadhouders,
  • Vassilis Roukos,
  • Kristian Vlahovicek,
  • Guillaume J. Filion,
  • Marina Lusic

DOI
https://doi.org/10.1038/s41467-019-12046-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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HIV-1 usually targets active genes and integrates near the nuclear pore compartment. Here the authors show that recurrently targeted genes are proximal to super-enhancer genomic elements, which cluster in specific spatial compartments of the T cell nucleus, suggesting a role for nuclear organisation in viral infection.