Репродуктивная эндокринология (Dec 2018)
Predictors of reproductive health disorders
Abstract
«Bell» indicating a change in reproductive health is menstrual cycle disorders. 10–28% of the total number of endocrine gynecological diseases is menstrual cycle disorders, its clinical manifestations are absence of menstruation or rare or poor menstruation, as well as subclinical manifestations in the form of infertility and miscarriage. If there is irregular menstrual cycle, it is necessary to consider the diagnosis of polycystic ovary syndrome. In the International evidence-based guideline for the assessment and management of polycystic ovary syndrome from 2018, a new treatment site appears phytotherapy, which has a hormone-correcting action. Its use is due to the fact that the polycystic ovaries syndrome is a life-long condition and need of long-term correction. For these purpose phytohormones without estrogenpositive activity flavonoids are used. Tazalok™ is one of such drugs. It blocks estrogen (androgen) receptors in the mammary glands, ovaries and uterus, normalizes estrogen-progestin balance (restores the hormonal balance). It has been established that correlation between the hormones of the adipose tissue and the indices of the functional activity of the hypothalamic-adrenal and hypothalamic-oocyte systems in patients with polycystic ovaries syndrome is lost. In this regard, a study was conducted to investigate the possibility of using the multicomponent herbal preparation Tazalok™ in the complex treatment of polycystic ovary syndrome in women with obesity and normal level of ovarian androgens. As a result, it was found that the inclusion in the treatment scheme of this drug gives possible normalize the function of adipose tissue and improve its relationship with the pituitary-adrenal and pituitar-ovarian systems, normalize the menstrual cycle. If it is necessary to restore the menstrual cycle the combined oral contraceptives should also be prescribed. They restore the menstrual cycle, which is the prevention of endometrial cancer, eliminating hypomenorrhea and hyperpolymenorrhea. The higher dose of estrogen in combined oral contraceptives is better kept the cycle, lead to less bleeding, but there is higher the thrombotic risk.
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