Терапевтический архив (Aug 2017)

Allergic bronchopulmonary aspergillosis in patients with asthma: Results of a prospective study

  • Ya I Kozlova,
  • E V Frolova,
  • L V Filippova,
  • A E Uchevatkina,
  • O V Aak,
  • N N Klimko

DOI
https://doi.org/10.17116/terarkh201789813-16
Journal volume & issue
Vol. 89, no. 8
pp. 13 – 16

Abstract

Read online

Aim. To estimate the frequency of fungal sensitization and the incidence of allergic bronchopulmonary aspergillosis (ABPA) in asthmatic patients. Subjects and methods. A total of 140 asthmatic patients were examined. They underwent allergologic (skin tests for fungal allergens, estimation of total and fungal allergen-specific IgE levels) and mycological (microscopy and inoculation of respiratory biosubstrates) examinations. Chest computed tomography, when indicated, was done. A group of patients with ABPA and that of patients with severe asthma and fungal sensitization were identified. Results. The frequency of fungal sensitization in asthmatic patients was 36%; the main allergenic fungi were Aspergillus and Alternaria. The incidence of ABPA was as high as 4% in the patients with asthma and 11% in those with severe asthma and fungal sensitization. Conclusion. The given current diagnostic criteria will assist practitioners to identify ABPA, to prevent its progression, and to initiate specific anti-inflammatory and antifungal therapy in due time.

Keywords