Clinical characteristics of coronavirus disease 2019 in a Chongqing hospital: analysis of 89 cases

Abstract

Objective To analyze the clinical characteristics of 89 cases of coronavirus disease 2019 (COVID-19) in Yongchuan Hospital of Chongqing Medical University. Methods The epidemiological data, clinical symptoms and results of laboratory tests of 89 COVID-19 patients admitted in our hospital from January 22 to February 17 2020 were collected and retrospectively analyzed. Results Fever and cough were the main symptoms of COVID-19, but there were 6 asymptomatic carriers in the cohort. The severe group had significantly lower lymphocyte absolute value, lymphocyte percentage, and the counts of CD3+, CD4+ and CD8+ cells when compared with the ordinary group (P < 0.05). The severe group also had obviously high levels of C-reactive protein and IL-6 than the ordinary and mild groups (P < 0.05). The severity of the disease was positively correlated with age, type 2 diabetes, C-reactive protein and IL-6 levels, and negatively correlated with the counts of lymphocytes, CD3+, CD4+ and CD8+ cells. Multivariate Logistic regression analysis indicated that increased C-reactive protein and decreased CD8+ cell count were independent factors for the severity of the condition. Conclusion Fever and cough are the main symptoms of COVID-19. C-reactive protein and CD8+ cell count are helpful for the assessment of the disease, and immune function is closely related to the severity of the disease.coronavirus disease 2019

Keywords

• coronavirus disease 2019
• clinical characteristics
• t lymphocyte
• c-reactive protein
• interleukin 6