Data on metabolic profile of insulin-degrading enzyme knockout mice
Diego O. Borges,
Maria João Meneses,
Tânia R. Dias,
Fátima O. Martins,
Pedro F. Oliveira,
Marco G. Alves,
M. Paula Macedo
Affiliations
Diego O. Borges
CEDOC – Centro de Estudos de Doenças Crónicas, NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal; Molecular Bioscience PhD Programme, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, ITQB-NOVA, Oeiras, Portugal
Maria João Meneses
CEDOC – Centro de Estudos de Doenças Crónicas, NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal; Department of Microscopy, Laboratory of Cell Biology and Unit for Multidisciplinary Research in Biomedicine (UMIB), Abel Salazar Institute of Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal; ProRegeM PhD Programme, NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal
Tânia R. Dias
Department of Microscopy, Laboratory of Cell Biology and Unit for Multidisciplinary Research in Biomedicine (UMIB), Abel Salazar Institute of Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal
Fátima O. Martins
CEDOC – Centro de Estudos de Doenças Crónicas, NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal
Pedro F. Oliveira
Department of Microscopy, Laboratory of Cell Biology and Unit for Multidisciplinary Research in Biomedicine (UMIB), Abel Salazar Institute of Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal; I3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal; Department of Genetics, Faculty of Medicine, University of Porto, Portugal
Marco G. Alves
Department of Microscopy, Laboratory of Cell Biology and Unit for Multidisciplinary Research in Biomedicine (UMIB), Abel Salazar Institute of Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal
M. Paula Macedo
CEDOC – Centro de Estudos de Doenças Crónicas, NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal; Portuguese Diabetes Association - Education and Research Center (APDP-ERC), Lisbon, Portugal; Department of Medical Sciences, University of Aveiro, Portugal; Corresponding author. CEDOC, Nova Medical School, Rua Câmara Pestana no 6, 6A, 1150-082, Lisboa, Portugal.
Insulin-degrading enzyme (IDE) degrades and inactivates bioactive peptides such as insulin. As insulin is a master regulator of glucose homeostasis, lack of IDE is expected to have a profound impact on both insulin and glucose levels. This article shares data on glucose and insulin homeostasis of control, heterozygous and knockout mice for Ide after 18 weeks of a normal chow diet. This data article is related to a research article entitled “Knockout of insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality” (Meneses et al., 2019).
