Screening and identification of prognostic genes associated with eosinophilic features of clear cell renal cell carcinoma
Tuanjie Guo,
Liren Jiang,
Tao Wang,
Jian Zhang,
Yang Liu,
Xuan Wang,
Ning Zhang,
Siteng Chen,
Xiang Wang
Affiliations
Tuanjie Guo
Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Liren Jiang
Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Tao Wang
Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Jian Zhang
Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Yang Liu
Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Xuan Wang
Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Ning Zhang
Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Corresponding author.
Siteng Chen
Corresponding author.; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Xiang Wang
Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Corresponding author.
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma, which is characterized by transparent cytoplasm. However, some ccRCC also show eosinophilic cytoplasm, and the molecular difference between eosinophilic and clear subtypes is unclear. In this study, we uncovered that under an optical microscope ccRCC with eosinophilic features has a poor prognosis. Eosinophilic ccRCC tends to have a higher histologic grade. Eosinophilic ccRCC has 16 genes significantly up-regulated compared with ccRCC, of which seven genes have multi-cohort validation prognostic value. Immune infiltration analysis suggested a low number of M1 macrophages and NK tissue-resident cells in eosinophilic ccRCC. Enrichment analysis suggests that ccRCC with eosinophilic features may be closely associated with the transport and metabolism of many substances. The findings of this study have important implications for the study of the malignant transformation of ccRCC.
