Case Reports in Medicine (Jan 2015)

Hemophagocytic Lymphohistiocytosis Complicating Dengue and Plasmodium vivax Coinfection

  • Muhammad Khurram,
  • Muhammad Faheem,
  • Muhammad Umar,
  • Asif Yasin,
  • Wajeeha Qayyum,
  • Amna Ashraf,
  • Javeria Zahid Khan,
  • Ali Hasnain Yasir,
  • Yusra Ansari,
  • Muhammad Asad,
  • Iram Khan,
  • Shuja Abbas,
  • Irum Rasheed,
  • Natasha Rasool,
  • Hamama Tul Bushra Khar

DOI
https://doi.org/10.1155/2015/696842
Journal volume & issue
Vol. 2015

Abstract

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Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder. Dysfunction of cytotoxic T and natural killer (NK) cells causes uncontrolled activity of lymphocytes and histiocytes which leads to HLH. Infections, malignancies, and autoimmune disorders are associated with development of HLH. Dengue and Plasmodium vivax are rare causes of HLH. We report the first ever case of a young man who developed fatal HLH that complicated Dengue Hemorrhagic Fever (DHF) and Plasmodium vivax infection.