Nature Communications (Jun 2022)

Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery

  • Marie-Christine Vaney,
  • Mariano Dellarole,
  • Stéphane Duquerroy,
  • Iris Medits,
  • Georgios Tsouchnikas,
  • Alexander Rouvinski,
  • Patrick England,
  • Karin Stiasny,
  • Franz X. Heinz,
  • Félix A. Rey

DOI
https://doi.org/10.1038/s41467-022-31111-y
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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The mechanism of flavivirus activation for membrane fusion is not yet understood. Here, Vaney et al. describe how the viral pr protein, derived from an HSP40/DnaJ chaperonin, interacts with a pH sensing loop in the envelope protein E for fusogenic activation.