Frontiers in Cell and Developmental Biology (Dec 2021)

Regulation of Mitochondrial Function by the Actin Cytoskeleton

  • María Illescas,
  • Ana Peñas,
  • Joaquín Arenas,
  • Joaquín Arenas,
  • Miguel A. Martín,
  • Miguel A. Martín,
  • Cristina Ugalde,
  • Cristina Ugalde

DOI
https://doi.org/10.3389/fcell.2021.795838
Journal volume & issue
Vol. 9

Abstract

Read online

The regulatory role of actin cytoskeleton on mitochondrial function is a growing research field, but the underlying molecular mechanisms remain poorly understood. Specific actin-binding proteins (ABPs), such as Gelsolin, have also been shown to participate in the pathophysiology of mitochondrial OXPHOS disorders through yet to be defined mechanisms. In this mini-review, we will summarize the experimental evidence supporting the fundamental roles of actin cytoskeleton and ABPs on mitochondrial trafficking, dynamics, biogenesis, metabolism and apoptosis, with a particular focus on Gelsolin involvement in mitochondrial disorders. The functional interplay between the actin cytoskeleton, ABPs and mitochondrial membranes for the regulation of cellular homeostasis thus emerges as a new exciting field for future research and therapeutic approaches.

Keywords