Polycationic Photosensitizers as Effective Anticancer Agents That Destroy Cancer Stem Cells, Cancer Vascularization and Induce Protective Desmoplastic Reaction around Lung Cancers
Evgeniya Kogan,
Gennady Meerovich,
Saida Karshieva,
Elena Makarova,
Igor Romanishkin,
Ekaterina Akhlyustina,
Irina Meerovich,
Nikolay Zharkov,
Sergey Kharnas,
Vladimir Levkin,
Sofya Demura,
Zhilong Chen,
Victor Loschenov,
Igor Reshetov
Affiliations
Evgeniya Kogan
Institute of Clinical Morphology and Digital Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia
Gennady Meerovich
Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia
Saida Karshieva
N.N. Blokhin National Medical Research Center of Oncology, Moscow 115478, Russia
Elena Makarova
Organic Intermediates and Dyes Institute, Moscow 123001, Russia
Igor Romanishkin
Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia
Ekaterina Akhlyustina
Institute of Engineering Physics for Biomedicine, National Research Nuclear University MEPhI, Moscow 115409, Russia
Irina Meerovich
A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russia
Nikolay Zharkov
Center of Digital Biodesign and Personalized Healthcare, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia
Sergey Kharnas
N.V. Sklifosovskiy Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia
Vladimir Levkin
N.V. Sklifosovskiy Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia
Sofya Demura
Institute of Clinical Morphology and Digital Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia
Zhilong Chen
Huadong Hospital, Fudan University, Shanghai 200433, China
Victor Loschenov
Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia
Igor Reshetov
L.L. Levshin Institute of Cluster Oncology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia
PDT using PSs based on polycationic derivatives of synthetic bacteriochlorin against Lewis lung carcinoma provides effective inhibition of tumor growth with an increase in the lifespan and survival of mice in the group. PDT with polycationic photosensitizers destroys CSCs and tumor neovascularization, and activates the desmoplastic reaction. These results open up new opportunities for increasing the effectiveness of treatment and reducing the incidence of relapses and metastases after PDT.
