The potential of RNA methylation in the treatment of cardiovascular diseases
Kai Wang,
YuQin Wang,
YingHui Li,
Bo Fang,
Bo Li,
Wei Cheng,
Kun Wang,
SuMin Yang
Affiliations
Kai Wang
Department of Cardiovascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, China; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266021, China
YuQin Wang
Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266021, China
YingHui Li
Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266021, China
Bo Fang
Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266021, China
Bo Li
Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266021, China
Wei Cheng
Department of Cardiovascular Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China; Corresponding author
Kun Wang
Department of Cardiovascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, China; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266021, China; Corresponding author
SuMin Yang
Department of Cardiovascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, China; Corresponding author
Summary: RNA methylation has emerged as a dynamic regulatory mechanism that impacts gene expression and protein synthesis. Among the known RNA methylation modifications, N6-methyladenosine (m6A), 5-methylcytosine (m5C), 3-methylcytosine (m3C), and N7-methylguanosine (m7G) have been studied extensively. In particular, m6A is the most abundant RNA modification and has attracted significant attention due to its potential effect on multiple biological processes. Recent studies have demonstrated that RNA methylation plays an important role in the development and progression of cardiovascular disease (CVD). To identify key pathogenic genes of CVD and potential therapeutic targets, we reviewed several common RNA methylation and summarized the research progress of RNA methylation in diverse CVDs, intending to inspire effective treatment strategies.
