Further Successes of the Meisenheimer Model

Abstract

Our simple Meisenheimer model for predicting the principal site for nucleophilic substitution in aromatic perfluorocarbons is further tested on a series of recently published reactions in liquid ammonia primarily from Malykhin and coworkers. The model accurately predicts the experimental results for all of the reactions reported further confirming its general applicability.

Keywords

• nucleophilic substitution
• fluorine-containing hetero-aromatics
• Meisenheimer model