Gene expression analysis of proliferation and apoptosis depending on the status of steroid hormone receptors in breast cancer

Abstract

In normal cell apoptosis and proliferation are strictly controlled by intra- and extracell mechanisms. These signals interfere with cell pathways through cell receptors, estrogen, progesterone, HER2/neu receptors in the case of breast cancer. Expression of apoptotic and proliferative genes is different in breast cancer depending on hormonal status. Besides correlation analysis shows different role of cell receptors in proliferation control in normal and breast tissue.

Keywords

• пролиферация
• апоптоз
• экспрессия генов
• рецепторы