A prospective observational study on maternal thyroid-stimulating hormone and its impact on maternal and perinatal outcome

Abstract

Background: Numerous hormonal changes and metabolic demands occur during pregnancy, resulting in complex changes in maternal thyroid function. Thyroid disorder is the second most common endocrine disorder found in pregnancy next to the diabetes group. It affects 1–2% of women of reproductive age. Overt hypothyroidism complicates 0.3–0.5% of pregnancies. The incidence of subclinical hypothyroidism in pregnant women is about 2–3%. Hyperthyroidism is present in 0.1–0.4%. Aims and Objectives: The aim of the study was to assess the maternal thyroid function test during pregnancy and its effect on maternal and fetal outcomes. Materials and Methods: A prospective observational study was conducted in the Department of Obstetrics and Gynaecology at Dhanalakshmi Srinivasan Medical College and Hospital, Tamil Nadu over a period of 1 year February 2019 to January 2020. The study is to screen pregnant women for thyroid disorders based on their serum thyroid stimulating hormone (TSH) at the first antenatal visit and its impact on maternal and perinatal outcomes. Results: In our study, overall thyroid abnormality incidence was found to be 5.5%. It is statistically significant (P3 kg was 18.2%. Perinatal outcomes were in terms of preterm, intrauterine growth restriction, low birthweight, and fetal distress. Conclusion: All pregnant women irrespective of their low risks or high risks for a thyroid disorder should be screened for serum TSH at the first booking visit to prevent the maternal and perinatal complications of thyroid disorders and close monitoring and effective treatment could be provided to them.

Keywords

• subclinical thyroid disorder; enzyme-linked immune sorbent assay
• thyroid function test; thyroid-stimulating hormone receptor antibodies