Abnormal Na-K-ATPase activity in erythrocytes from patients with diabetes mellitus

Abstract

Aim. To measure Na-K-ATPase activity in erythrocytes from patients with diabetes mellitus (DM), elucidate its relationship with clinical manifestationsof the disease and biochemical blood characteristics. Materials and methods. A total of 76 DM patients were enrolled in this study (39 with DM1 and 35 with DM2). Control group consisted of 11 subjectswithout DM. They were examined for HbA1c, nitrite and nitrate levels in blood and membranes, sialidase activity in erythrocytes and Na-KATPaseactivity measured from variations of inorganic phosphorus content in the presence of ATP. Results. Na-K-ATPase activity in MD patients was significantly lower than in controls (p

Keywords

• na-k-atpase
• electrolyte gradient across plasma membrane
• c peptide
• diabetic neuropathy