Association of vitamin D and inflammatory biomarkers with newly diagnosed cases of hypothyroidism- A case-control study

Abstract

Background: Deranged thyroid hormones and TSH induces the release of inflammatory biomarkers and recent evidence has demonstrated an association between low vitamin D status and autoimmune thyroid diseases, but there is little documented evidence available about the association of vitamin D and inflammatory biomarkers. So, this study was planned to investigate the relationship between vitamin D and inflammatory biomarkers. Materials and Methods: This case-control study was carried out among 60 study participants (30 cases and 30 controls) in the Department of Biochemistry, F.H Medical College, its associated Hospital from January 2023 to June 2023 The samples were divided in to two groups, cases (hypothyroid patients) and healthy control group. Serum was separated by centrifuging blood at 3000 rpm for 10 mi. Estimation of CRP was done turbidimetric immune assay method. Statistical analysis was done by using the (SPSS) version 20.0. Pearson correlation and Student’s t-test was applied, p-value <0.0001 was taken as significance. Results: The (mean ±SD) CRP values in the subjects having hypothyroid disorder (cases) were 3.12± 0.79 mg/L and in control was 2.01±0.75 mg/L (p-value <0.0001). The weight was found to be higher in cases. The CRP and IL-6 had an insignificant correlation with the BMI (r=0.06, p=0.74) and (r=0.64, p=0.35) and also insignificant correlation was found in between the CRP and the blood pressure. Conclusion: This study concludes that CRP and IL-6 levels were significantly higher in hypothyroid patients and insignificant correlation was found between anthropometric measurements of hypothyroid patients and inflammatory biomarkers.

Keywords

• vitamin d
• crp
• il-6
• hypothyroidism
• hypothyroid patients