Nature Communications (Oct 2017)
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease
- Patrick Lüningschrör,
- Beyenech Binotti,
- Benjamin Dombert,
- Peter Heimann,
- Angel Perez-Lara,
- Carsten Slotta,
- Nadine Thau-Habermann,
- Cora R. von Collenberg,
- Franziska Karl,
- Markus Damme,
- Arie Horowitz,
- Isabelle Maystadt,
- Annette Füchtbauer,
- Ernst-Martin Füchtbauer,
- Sibylle Jablonka,
- Robert Blum,
- Nurcan Üçeyler,
- Susanne Petri,
- Barbara Kaltschmidt,
- Reinhard Jahn,
- Christian Kaltschmidt,
- Michael Sendtner
Affiliations
- Patrick Lüningschrör
- Institute of Clinical Neurobiology, University Hospital Würzburg
- Beyenech Binotti
- Department of Neurobiology, Max Planck Institute for Biophysical Chemistry
- Benjamin Dombert
- Institute of Clinical Neurobiology, University Hospital Würzburg
- Peter Heimann
- Department of Cell Biology, University of Bielefeld
- Angel Perez-Lara
- Department of Neurobiology, Max Planck Institute for Biophysical Chemistry
- Carsten Slotta
- Department of Cell Biology, University of Bielefeld
- Nadine Thau-Habermann
- Department of Neurology, Hannover Medical School
- Cora R. von Collenberg
- Institute of Clinical Neurobiology, University Hospital Würzburg
- Franziska Karl
- Department of Neurology, University Hospital Würzburg
- Markus Damme
- Institut für Biochemie, Christian-Albrechts-Universität zu Kiel
- Arie Horowitz
- Cardeza Vascular Biology Center, Departments of Medicine and Cancer Biology, Sidney Kimmel Medical College, Thomas Jefferson University
- Isabelle Maystadt
- Centre de Génétique Humaine, Institut de Pathologie et de Génétique
- Annette Füchtbauer
- Department of Molecular Biology and Genetics, Aarhus University
- Ernst-Martin Füchtbauer
- Department of Molecular Biology and Genetics, Aarhus University
- Sibylle Jablonka
- Institute of Clinical Neurobiology, University Hospital Würzburg
- Robert Blum
- Institute of Clinical Neurobiology, University Hospital Würzburg
- Nurcan Üçeyler
- Department of Neurology, University Hospital Würzburg
- Susanne Petri
- Department of Neurology, Hannover Medical School
- Barbara Kaltschmidt
- Department of Cell Biology, University of Bielefeld
- Reinhard Jahn
- Department of Neurobiology, Max Planck Institute for Biophysical Chemistry
- Christian Kaltschmidt
- Department of Cell Biology, University of Bielefeld
- Michael Sendtner
- Institute of Clinical Neurobiology, University Hospital Würzburg
- DOI
- https://doi.org/10.1038/s41467-017-00689-z
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
Accumulating evidence suggests that disruption of autophagy is associated with neurodegeneration. Here the authors show that Plekhg5 acts as a GEF for Rab26, a small GTPase that promotes the autophagy of synaptic vesicles in neurons; mice lacking Plekgh5 develop late-onset motoneuron degeneration.
