Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH

Sangeeta Chakraborty; Lin Liu; Liam Fitzsimmons; Steffen Porwollik; Ju-Sim Kim; Prerak Desai; Michael McClelland; Andres Vazquez-Torres

doi:10.1038/s41467-020-15604-2

Nature Communications (Apr 2020)

Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH

Sangeeta Chakraborty,
Lin Liu,
Liam Fitzsimmons,
Steffen Porwollik,
Ju-Sim Kim,
Prerak Desai,
Michael McClelland,
Andres Vazquez-Torres

Affiliations

Sangeeta Chakraborty: Department of Immunology & Microbiology, University of Colorado School of Medicine
Lin Liu: Department of Immunology & Microbiology, University of Colorado School of Medicine
Liam Fitzsimmons: Department of Immunology & Microbiology, University of Colorado School of Medicine
Steffen Porwollik: Department of Microbiology and Molecular Genetics, University of California Irvine School of Medicine
Ju-Sim Kim: Department of Immunology & Microbiology, University of Colorado School of Medicine
Prerak Desai: Department of Microbiology and Molecular Genetics, University of California Irvine School of Medicine
Michael McClelland: Department of Microbiology and Molecular Genetics, University of California Irvine School of Medicine
Andres Vazquez-Torres: Department of Immunology & Microbiology, University of Colorado School of Medicine

DOI: https://doi.org/10.1038/s41467-020-15604-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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Chakraborty et al. show that phagocyte NADPH oxidase (NOX2) collapses the ΔpH of intracellular Salmonella Typhimurium, leading to oxidative damage of cell envelope proteins. Salmonella responds by shifting redox balance from respiration to glycolysis and fermentation, thereby facilitating folding of periplasmic functions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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