The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs

Abstract

Back pain: overactive protein causes disc breakdown Treatments targeting a protein that is overexpressed in damaged spinal cartilage could ease degenerative conditions associated with lower back pain. The intervertebral discs are complex cartilage tissues that absorb forces while allowing the motion of our spines. An immune-promoting enzyme called calcineurin is important in maintaining the supple, gel-like structure of the central part of each disc, the nucleus pulposus (NP). Fendong Zhao and Jian Chen at Zhejiang University School of Medicine Hangzhou, China and co-workers showed that RCAN1.4, a protein known to suppress calcineurin, is overexpressed in damaged human NPs. The team further revealed how a signaling pathway starting with RCAN1.4 suppresses key genes involved in forming the collagen fibers that hold the NP together. They therefore suggest that therapies targeting this protein could benefit patients suffering from disc degeneration diseases.