Communications Biology (Jun 2021)

Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model

  • Megan K. Elder,
  • Hediye Erdjument-Bromage,
  • Mauricio M. Oliveira,
  • Maggie Mamcarz,
  • Thomas A. Neubert,
  • Eric Klann

DOI
https://doi.org/10.1038/s42003-021-02324-6
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 13

Abstract

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Elder et al. investigated the de novo proteome in isolated hippocampal slices of young APP/PS1 Alzheimer’s model mice and revealed that large-scale changes in protein synthesis precede symptom onset. These results suggest that broad dysregulation of protein synthesis could contribute toward cellular dysfunction in Alzheimer’s disease.