Communications Biology (Jun 2021)
Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model
Abstract
Elder et al. investigated the de novo proteome in isolated hippocampal slices of young APP/PS1 Alzheimer’s model mice and revealed that large-scale changes in protein synthesis precede symptom onset. These results suggest that broad dysregulation of protein synthesis could contribute toward cellular dysfunction in Alzheimer’s disease.