Acta Pharmaceutica Sinica B (Mar 2017)

Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities

  • Yufeng Liu,
  • Minghua Chen,
  • Qinglan Guo,
  • Yuhuan Li,
  • Jiandong Jiang,
  • Jiangong Shi

DOI
https://doi.org/10.1016/j.apsb.2016.09.004
Journal volume & issue
Vol. 7, no. 2
pp. 179 – 184

Abstract

Read online

A pair of new diphenyl glycerol ether enantiomers (−)-1 and (+)-1 and two new methyl benzamidobenzoates 2 and 3, named (−)-(R)- and (+)-(S)-isatindigotrioic acid [(−)-1 and (+)-1] and isatindigoticamides A (2) and B (3), respectively, were isolated from an aqueous decoction of the roots of Isatis indigotica (ban lan gen). Their structures were elucidated by spectroscopic data analysis including 2D NMR experiments. The absolute configurations of (−)-1 and (+)-1 were assigned based on the CD exciton chirality method. Compounds 2 and 3 exhibited antiviral activities against HSV-1 with IC50 values of 4.87 and 25.87 μmol/L, respectively. Compound 2 was also found active against Coxsackie virus B3 and LPS-induced NO production.

Keywords