Integrated model for segmentation of glomeruli in kidney images

Abstract

Kidney diseases, especially those that affect the glomeruli, have become more common worldwide in recent years. Accurate and early detection of glomeruli is critical for accurately diagnosing kidney problems and determining the most effective treatment options. Our study proposed an advanced model, FResMRCNN, an enhanced version of Mask R-CNN, for automatically detecting and segmenting the glomeruli in PAS-stained human kidney images. The model integrates the power of FPN with a ResNet101 backbone, which was selected after assessing seven different backbone architectures. The integration of FPN and ResNet101 into the FResMRCNN model improves glomeruli detection, segmentation accuracy and stability by representing multi-scale features. We trained and tested our model using the HuBMAP Kidney dataset, which contains high-resolution PAS-stained microscopy images. During the study, the effectiveness of our proposed model is examined by generating bounding boxes and predicted masks of glomeruli. The performance of the FResMRCNN model is evaluated using three performance metrics, including the Dice coefficient, Jaccard index, and binary cross-entropy loss, which show promising results in accurately segmenting glomeruli.

Keywords

• Glomeruli
• Segmentation
• FResMRCNN
• ResNet101
• HuBMAP dataset
• Kidney