A MUB E2 structure reveals E1 selectivity between cognate ubiquitin E2s in eukaryotes

Abstract

Regulators of the important ubiquitylation cascade are not well studied. Here, the authors report the crystal structure of a prenylated membrane-anchored ubiquitin-fold protein from Arabidopsisbound to an E2 protein and conclude that it is an example of selective activation between E2 enzymes.