Фармакокинетика и Фармакодинамика (Oct 2019)

Comparison of neuroprotective properties of the dipeptide mimetics of the 1st, 2nd and 4th loops of the brain-derived neurotrophic factor on the model oxidative stress in vitro

  • I. O. Logvinov,
  • A. V. Tarasiuk,
  • N. M. Sazonova,
  • P. I. Antipov,
  • T. A. Antipova,
  • T. A. Gudasheva

DOI
https://doi.org/10.24411/2587-7836-2018-10022.
Journal volume & issue
Vol. 0, no. 3
pp. 37 – 41

Abstract

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Resume. The purpose of this study was to compare neuroprotective properties of the dimeric dipeptide mimetics of the 1st, 2nd and 4th Loops of BDNF - GSB-214 (heptamethylenediamide bis-monosuccinyl-methionyl-serine), GTS-201 (hexamethylenediamide bis-hexanoyl-seryl-lysine) and GSB-106 (hexamethylenediamide bis-monosuccinyl-seryl-lysine) in the HT-22 hippocampal cells in conditions of oxidative stress. It has been established that the mimetic of the 4th loop of BDNF shows a neuroprotective effect in lower concentrations compared to mimetics based on the 1st and 2nd loops when applied 24 hours before and immediately after the damages.

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