Multiple sclerosis: evidence and controversies

Abstract

Introduction: Multiple sclerosis is a chronicrecurrent inflammatory disorder of the centralnervous system. The pharmacological treatmentof multiple sclerosis has been evaluated withmultiple controlled clinical trials that allow theclinician to count with evidence based informationto decide the more indicated treatmentfor each patient.Methodology: A review of the scientific literaturewas conducted to clarify controversialissues in a clinical relevant topic.Development: The diagnostic criteria anddifferent treatments available are reviewed, inorder to consider the clinical utility of the disease modifying agents such as the immunomodulatorytreatments. The three used types ofinterferon are well tolerated and reduce in approximatelya third the number of bouts in theremitent recurrent form; there is no significantdifference between the three of them.

Keywords

• Multiple sclerosis
• diagnosis
• interferons