Repeated Lineage Switches in an Elderly Case of Refractory B-Cell Acute Lymphoblastic Leukemia With MLL Gene Amplification: A Case Report and Literature Review

• Reina Takeda,
• Kazuaki Yokoyama,
• Tomofusa Fukuyama,
• Tomofusa Fukuyama,
• Toyotaka Kawamata,
• Toyotaka Kawamata,
• Mika Ito,
• Nozomi Yusa,
• Rika Kasajima,
• Rika Kasajima,
• Eigo Shimizu,
• Nobuhiro Ohno,
• Nobuhiro Ohno,
• Nobuhiro Ohno,
• Kaoru Uchimaru,
• Kaoru Uchimaru,
• Rui Yamaguchi,
• Seiya Imoto,
• Satoru Miyano,
• Arinobu Tojo,
• Arinobu Tojo

Affiliations

Reina Takeda

Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Kazuaki Yokoyama

Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Tomofusa Fukuyama

Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Tomofusa Fukuyama

Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Toyotaka Kawamata

Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Toyotaka Kawamata

Division of Molecular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan

Mika Ito

Division of Molecular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan

Nozomi Yusa

Department of Applied Genomics, Research Hospital, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Rika Kasajima

Division of Health Medical Data Science, Health Intelligence Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Rika Kasajima

Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan

Eigo Shimizu

Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Nobuhiro Ohno

Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Nobuhiro Ohno

Division of Molecular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan

Nobuhiro Ohno

Department of Hematology, Kanto Rosai Hospital, Kanagawa, Japan

Kaoru Uchimaru

Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Kaoru Uchimaru

Laboratory of Tumor Cell Biology, Department of Computational Biology and Medical Science, Graduate School of the Frontier Science, The University of Tokyo, Tokyo, Japan

Rui Yamaguchi

Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Seiya Imoto

Division of Health Medical Data Science, Health Intelligence Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Satoru Miyano

Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Arinobu Tojo

Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Arinobu Tojo

Division of Molecular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan