PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response

Zdenek Andrysik; Kelly D. Sullivan; Jeffrey S. Kieft; Joaquin M. Espinosa

doi:10.1038/s41467-022-35089-5

Nature Communications (Dec 2022)

PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response

Zdenek Andrysik,
Kelly D. Sullivan,
Jeffrey S. Kieft,
Joaquin M. Espinosa

Affiliations

Zdenek Andrysik: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
Kelly D. Sullivan: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
Jeffrey S. Kieft: Department of Biochemistry and Molecular Genetics and RNA Bioscience Initiative, University of Colorado Anschutz Medical Campus
Joaquin M. Espinosa: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus

DOI: https://doi.org/10.1038/s41467-022-35089-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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The authors describe a functional crosstalk between the p53 network and the integrated stress response through the p53 repressor PPM1D. Inhibition of PPM1D potentiates p53-dependent transactivation and apoptosis via induction of the HRI-eIF2α-ATF4 pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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