Endothelial cell-specific expression of serine/threonine kinase 11 modulates dendritic cell differentiation

Qiang Zhao; Young-Min Han; Ping Song; Zhixue Liu; Zuyi Yuan; Ming-Hui Zou

doi:10.1038/s41467-022-28316-6

Nature Communications (Feb 2022)

Endothelial cell-specific expression of serine/threonine kinase 11 modulates dendritic cell differentiation

Qiang Zhao,
Young-Min Han,
Ping Song,
Zhixue Liu,
Zuyi Yuan,
Ming-Hui Zou

Affiliations

Qiang Zhao: Center for Molecular and Translational Medicine, Georgia State University
Young-Min Han: Center for Molecular and Translational Medicine, Georgia State University
Ping Song: Center for Molecular and Translational Medicine, Georgia State University
Zhixue Liu: Center for Molecular and Translational Medicine, Georgia State University
Zuyi Yuan: Department of Cardiology, First Affiliated Hospital of Xi’an Jiaotong University
Ming-Hui Zou: Center for Molecular and Translational Medicine, Georgia State University

DOI: https://doi.org/10.1038/s41467-022-28316-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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In the bone marrow, dendritic cell development is governed by supporting cells, such as endothelial cells. Here authors show that expression of serine/threonine kinase 11 in endothelial cells regulates differentiation of dendritic cell precursors via modulating secretion of stem cell factor.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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