Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation

Hayden Weng Siong Tan; Arthur Yi Loong Sim; Yun Chau Long

doi:10.1038/s41467-017-00369-y

Nature Communications (Aug 2017)

Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation

Hayden Weng Siong Tan,
Arthur Yi Loong Sim,
Yun Chau Long

Affiliations

Hayden Weng Siong Tan: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
Arthur Yi Loong Sim: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
Yun Chau Long: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore

DOI: https://doi.org/10.1038/s41467-017-00369-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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mTORC1 is a critical kinase that regulates cell growth and proliferation. Here the authors show that glutamine metabolism is sufficient to restore mTORC1 activity during prolonged amino acid starvation in an autophagy-dependent manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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