Association of clinical characteristics and vaccines with risk of persistently viral clearance in patients infected with SARS-CoV-2 Omicron variant in Shanghai, China
Wen Zhang,
Hongze Wu,
Quan Guo,
Xiangru Xu,
Yuting Pu,
Caiyu Chen,
Min Cao,
Ding Sun,
Wei Lu,
Hui Yi,
Shuang Zhou,
Bangjiang Fang
Affiliations
Wen Zhang
Department of Emergency, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, PR China
Hongze Wu
Jiujiang Traditional Chinese Medicine Hospital, Jiujiang, 332005, Jiangxi, PR China
Quan Guo
Department of Emergency, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, PR China
Xiangru Xu
Department of Emergency, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, PR China
Yuting Pu
Department of Emergency, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, PR China
Caiyu Chen
Department of Emergency, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, PR China
Min Cao
Department of Emergency, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, PR China
Ding Sun
Department of Rheumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, PR China
Wei Lu
Department of Nursing, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, PR China
Hui Yi
Jiujiang Traditional Chinese Medicine Hospital, Jiujiang, 332005, Jiangxi, PR China
Shuang Zhou
School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, 1200 Cai Lun Road, Zhangjiang Hi Tech Park, Pudong New Area, Shanghai 201203, PR China; Corresponding author. School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, 1200 Cai Lun Road, Zhangjiang Hi Tech Park, Pudong New Area, Shanghai 201203, PR China.
Bangjiang Fang
Department of Emergency, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, PR China; Institute of Emergency and Critical Care Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, PR China; Corresponding author. Department of Emergency, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Institute of Acute and Critical Care, Shanghai University of Traditional Chinese Medicine, NO. 725, Wanping South Road, Xuhui District, Shanghai 200032, PR China.
Importance: The global COVID-19 pandemic does not appear to end in the near future. Currently, limited data are available on the risk factors for delayed viral clearance in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant infection. Objective: This study aimed to investigate the association of clinical characteristics and vaccination with prolonged viral clearance. Methods: This retrospective cohort included 16,985 patients who had contracted the SARS-CoV-2 Omicron variant between April 5 and May 30, 2022, in Shanghai, China, and had mild or no symptoms. The patients were admitted to the quarantine venue at the Shanghai New International Expo Center. Results: Of the 16,985 participants, the occurrence of viral clearance was ≤8 and > 8 days in 11,009 (64.8 %) and 5976 (35.2 %) participants, respectively. Risk factors related to patients who remained persistently polymerase chain reaction (PCR)-positive were sex (Male, odds ratio [OR] 1.221, p 35, OR 0.079, p < 0.001). The lower rates of increase in Ct values were observed in the later viral shedding group than in the early viral shedding group for ORF1ab (β = −0.791, p < 0.001) and N genes (β = −0.825, p < 0.001). Conclusion: Prolonged SARS-CoV-2 RNA detection and higher viral concentrations were associated with factors such as male sex, older age, symptomatic status, and fewer doses of vaccination in patients admitted to Shanghai Makeshift Hospital between April 5 and May 30, 2022.
