Role of Nuclear Receptors in Spontaneous and Recurrent Miscarriage

Abstract

Although early pregnancy loss is a common complication of human reproduction, a significant proportion of miscarriages still happen for unknown reasons. Nuclear receptors are key players in trophoblast invasion and metabolism; therefore, their agonists and ligands are a promising target for the prevention of miscarriage. This review gives an overview of the existing data and literature concerning the involvement of nuclear receptors in maintaining a viable pregnancy.

Keywords

• miscarriage
• recurrent miscarriage
• nuclear receptor
• peroxisome proliferator-activated receptor (ppar)
• retinoid x receptor (rxr)
• liver x receptor (lxr)
• thyroid hormone receptor (thr)