Urogenital haemorrhage secondary to Babesia gibsoni induced immune thrombocytopenia and its management with combination of romiplostim and prednisolone in a dog
Nadima Khan,
Anindita Sandilya,
J. Kiran,
Arindam Bhowmik,
Gourav Debnath,
Neeraj Thakur,
H. Lalrinkima,
Kalyan Sarma,
Bedanga Konwar,
G.E. Chethan
Affiliations
Nadima Khan
Department of Veterinary Medicine, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (Imphal), Selesih, Aizawl, Mizoram 796015, India
Anindita Sandilya
Department of Veterinary Medicine, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (Imphal), Selesih, Aizawl, Mizoram 796015, India
J. Kiran
Department of Veterinary Pathology, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (Imphal), Selesih, Aizawl, Mizoram 796015, India
Arindam Bhowmik
Department of Veterinary Medicine, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (Imphal), Selesih, Aizawl, Mizoram 796015, India
Gourav Debnath
Department of Veterinary Medicine, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (Imphal), Selesih, Aizawl, Mizoram 796015, India
Neeraj Thakur
Department of Veterinary Medicine, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (Imphal), Selesih, Aizawl, Mizoram 796015, India
H. Lalrinkima
Department of Veterinary Parasitology, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (Imphal), Selesih, Aizawl, Mizoram 796015, India
Kalyan Sarma
Department of Veterinary Medicine, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (Imphal), Selesih, Aizawl, Mizoram 796015, India
Bedanga Konwar
Department of Veterinary Surgery and Radiology, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (Imphal), Selesih, Aizawl, Mizoram 796015, India
G.E. Chethan
Department of Veterinary Medicine, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (Imphal), Selesih, Aizawl, Mizoram 796015, India; Corresponding author.
In this report, urogenital haemorrhage secondary to Babesia gibsoni induced immune thrombocytopenia (ITP) in a mixed breed dog (non-pedigreed crossbred without available ancestry) and its therapeutic management with combination of romiplostim and prednisolone has been described. A seven year old male mixed breed dog was presented with a history of inappetance, lethargy, weakness, and sudden bleeding from the urogenital orifice. Clinical and laboratory examinations revealed pale mucous membranes, popliteal lymphadenopathy, anaemia and pronounced thrombocytopenia. Microscopic blood smear examination, rapid antibody detection by using a commercially available kit, and polymerase chain reaction (PCR) followed by sequencing confirmed B. gibsoni infection. Saline agglutination test, spherocytosis and presence of ghost cells were diagnostic of immune-mediated haemolytic anaemia (IMHA). The dog was stabilized using intravenous plasma volume expander, and triple drug therapy comprising doxycycline, clindamycin and metronidazole. A combination of prednisolone and romiplostim was administered to combat IMHA and ITP. Oral triple drug therapy along with supportive treatment was continued for a total of twenty eight days. The animal showed uneventful recovery after the completion of treatment regimen.
