Frontiers in Immunology (Feb 2023)

Effect of extracorporeal hemoadsorption in critically ill patients with COVID-19: A narrative review

  • Kaixi Chang,
  • Yupei Li,
  • Zheng Qin,
  • Zhuyun Zhang,
  • Liya Wang,
  • Qinbo Yang,
  • Jiwen Geng,
  • Ningyue Deng,
  • Shanshan Chen,
  • Baihai Su,
  • Baihai Su,
  • Baihai Su

DOI
https://doi.org/10.3389/fimmu.2023.1074465
Journal volume & issue
Vol. 14

Abstract

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COVID-19 has been affecting the world unprecedentedly and will remain widely prevalent due to its elusive pathophysiological mechanism and the continuous emergence of new variants. Critically ill patients with COVID-19 are commonly associated with cytokine storm, multiple organ dysfunction, and high mortality. To date, growing evidence has shown that extracorporeal hemoadsorption can exert its adjuvant effect to standard of care by regulating immune homeostasis, reducing viremia, and decreasing endotoxin activity in critically ill COVID-19 cases. However, the selection of various hemofilters, timing of initiation and termination of hemoadsorption therapy, anticoagulation management of extracorporeal circuits, identification of target subgroups, and ultimate survival benefit remain controversial. The purpose of this narrative review is to comprehensively summarize the rationale for the use of hemoadsorption in critically ill patients with COVID-19 and to gather the latest clinical evidence in this field.

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