The Gut Microbiome Alterations in Pediatric Patients with Functional Abdominal Pain Disorders

Abstract

In this prospective longitudinal study, we enrolled 54 healthy pediatric controls and 28 functional abdominal pain disorders (FAPDs) pediatric patients (mean age was 11 ± 2.58 years old). Fecal samples and symptom questionnaires were obtained from all participants over the course of the year. Clinical data assessment showed that FAPDs patients were more symptomatic than the control group. Microbiome analysis revealed that Phylum Bacteroidetes was higher in FAPDs compared to the control group (p p p p p = 0.002) as well. Using linear discriminant analysis effect size (LEfSe), Enterobacteriaceae family and Megaspherae showed increased abundances in vacation term (LDA score > 2.0, LEfSe, p Faecalibacterium/Bacteroides ratio as a potential diagnostic biomarker for FAPDs.

Keywords

• gut microbiome
• FAPDs
• dysbiosis