Melanogenesis and the Targeted Therapy of Melanoma

Cang Li; Le Kuai; Rutao Cui; Xiao Miao

doi:10.3390/biom12121874

Biomolecules (Dec 2022)

Melanogenesis and the Targeted Therapy of Melanoma

Cang Li,
Le Kuai,
Rutao Cui,
Xiao Miao

Affiliations

Cang Li: Skin Disease Research Institute, Zhejiang University School of Medicine, Hangzhou 310058, China
Le Kuai: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
Rutao Cui: Skin Disease Research Institute, Zhejiang University School of Medicine, Hangzhou 310058, China
Xiao Miao: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China

DOI: https://doi.org/10.3390/biom12121874
Journal volume & issue: Vol. 12, no. 12
p. 1874

Abstract

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Pigment production is a unique character of melanocytes. Numerous factors are linked with melanin production, including genetics, ultraviolet radiation (UVR) and inflammation. Understanding the mechanism of melanogenesis is crucial to identify new preventive and therapeutic strategies in the treatment of melanoma. Here, we reviewed the current available literatures on the mechanisms of melanogenesis, including the signaling pathways of UVR-induced pigment production, MC1R’s central determinant roles and MITF as a master transcriptional regulator in melanogenesis. Moreover, we further highlighted the role of targeting BRAF, NRAS and MC1R in melanoma prevention and treatment. The combination therapeutics of immunotherapy and targeted kinase inhibitors are becoming the newest therapeutic option in advanced melanoma.

Published in Biomolecules

ISSN: 2218-273X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: https://www.mdpi.com/journal/biomolecules

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Abstract

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