Ferric sodium edetate therapy in children with iron deficiency anemia

Paediatrica Indonesiana. 2015;55(2):91-4 DOI 10.14238/pi55.2.2015.91-4

 

Journal Homepage

Journal Title: Paediatrica Indonesiana

ISSN: 0030-9311 (Print); 2338-476X (Online)

Publisher: Indonesian Pediatric Society Publishing House

Society/Institution: Indonesian Pediatric Society

LCC Subject Category: Medicine: Pediatrics

Country of publisher: Indonesia

Language of fulltext: English

Full-text formats available: PDF

 

AUTHORS

Christie Moningkey (Department of Child Health, Sam Ratulangi University Medical School/Prof. RD Kandou Hospital, Manado, Indonesia)
Max F.J. Mantik (Department of Child Health, Sam Ratulangi University Medical School/Prof. RD Kandou Hospital, Manado, Indonesia)
Vivekenanda Pateda (Department of Child Health, Sam Ratulangi University Medical School/Prof. RD Kandou Hospital, Manado, Indonesia)

EDITORIAL INFORMATION

Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 24 weeks

 

Abstract | Full Text

Background Iron deficiency anemia (IDA) is frequently found in school-aged children. The main treatments for IDA are overcoming the causal factors and iron supplementation. Noncompliance in taking iron tablets and the possibility of iron absorbtion or transport difficulties, can reduce efficacy of daily oral iron supplementation. Because excess iron storage in the intestinal cells can lead to mucosal blockage, twice weekly oral iron therapy may be considered instead of daily dosage. Objective To compare the effects of daily vs. twice weekly ferric sodium edetate (NaFeEDTA) on hemoglobin (Hb), hematocrit (Ht), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) levels on children with IDA. MethodsWe conducted an open-label, randomized, prospective study in 36 children with IDA aged 5-11 years. Subjects were divided into two groups. For a one-month period, group I received daily iron therapy (NaFeEDTA) and group II received twice weekly iron therapy. Examinations of Hb, Ht, MCV, MCH, MCHC were performed before and after iron therapy. Results There were no significant differences in Hb, Ht, MCV, MCH or MCHC levels after therapy between the daily and twice weekly NaFeEDTA groups (P > 0.05). Conclusion Twice weekly NaFeEDTA therapy is as effective as daily NaFeEDTA administration in children with IDA.