Nature Communications (Jul 2020)

TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing

  • Theresa Schöpp,
  • Ansgar Zoch,
  • Rebecca V. Berrens,
  • Tania Auchynnikava,
  • Yuka Kabayama,
  • Lina Vasiliauskaitė,
  • Juri Rappsilber,
  • Robin C. Allshire,
  • Dónal O’Carroll

DOI
https://doi.org/10.1038/s41467-020-17372-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 8

Abstract

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The PIWI protein MIWI2 counteracts transposon activity by transcriptional silencing in the mammalian germline. Here, the authors show that TEX15 interacts with MIWI2 and is required for piRNA-directed methylation of transposable elements in male germ cells.