Variable number of TMC1-dependent mechanotransducer channels underlie tonotopic conductance gradients in the cochlea

Maryline Beurg; Runjia Cui; Adam C. Goldring; Seham Ebrahim; Robert Fettiplace; Bechara Kachar

doi:10.1038/s41467-018-04589-8

Nature Communications (Jun 2018)

Variable number of TMC1-dependent mechanotransducer channels underlie tonotopic conductance gradients in the cochlea

Maryline Beurg,
Runjia Cui,
Adam C. Goldring,
Seham Ebrahim,
Robert Fettiplace,
Bechara Kachar

Affiliations

Maryline Beurg: Department of Neuroscience, University of Wisconsin School of Medicine and Public Health
Runjia Cui: Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
Adam C. Goldring: Department of Neuroscience, University of Wisconsin School of Medicine and Public Health
Seham Ebrahim: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Robert Fettiplace: Department of Neuroscience, University of Wisconsin School of Medicine and Public Health
Bechara Kachar: Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health

DOI: https://doi.org/10.1038/s41467-018-04589-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

Read online

Mechanoelectrical transduction channel (MET) current found in stereocilia of hair cells matures over the first postnatal week. Here the authors look at the contribution of transmembrane channel-like protein 1 and 2 (TMC1 and TMC2) to MET current during development of tonotopic gradients.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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