Label-free detection of conformational changes in switchable DNA nanostructures with microwave microfluidics

Angela C. Stelson; Minghui Liu; Charles A. E. Little; Christian J. Long; Nathan D. Orloff; Nicholas Stephanopoulos; James C. Booth

doi:10.1038/s41467-019-09017-z

Nature Communications (Mar 2019)

Label-free detection of conformational changes in switchable DNA nanostructures with microwave microfluidics

Angela C. Stelson,
Minghui Liu,
Charles A. E. Little,
Christian J. Long,
Nathan D. Orloff,
Nicholas Stephanopoulos,
James C. Booth

Affiliations

Angela C. Stelson: National Institute of Standards and Technology, Radio Frequency Electronics Group
Minghui Liu: School of Molecular Sciences, Arizona State University, 551 E University Dr
Charles A. E. Little: National Institute of Standards and Technology, Radio Frequency Electronics Group
Christian J. Long: National Institute of Standards and Technology, Radio Frequency Electronics Group
Nathan D. Orloff: National Institute of Standards and Technology, Radio Frequency Electronics Group
Nicholas Stephanopoulos: School of Molecular Sciences, Arizona State University, 551 E University Dr
James C. Booth: National Institute of Standards and Technology, Radio Frequency Electronics Group

DOI: https://doi.org/10.1038/s41467-019-09017-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

Read online

Methods to study conformational changes in biomolecules are limited in resolution and require labelling or other modifications of target analytes. Here the authors present a label-free, microwave microfluidic approach to detect conformational changes of DNA nanostructures based on ionic conductivity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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