Nature Communications (Feb 2022)

Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription

  • Benoît Arragain,
  • Quentin Durieux Trouilleton,
  • Florence Baudin,
  • Jan Provaznik,
  • Nayara Azevedo,
  • Stephen Cusack,
  • Guy Schoehn,
  • Hélène Malet

DOI
https://doi.org/10.1038/s41467-022-28428-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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La Crosse is a human life threatening virus belonging to the Bunyavirales order. The structure of its polymerase solved in seven key active states by cryo-electron microscopy reveals the molecular mechanisms of viral RNA replication and transcription.