Numerical Study of Voltage-Gated Ca<sup>2&#x002B;</sup> Transport Irradiated by Terahertz Electromagnetic Wave

Wenfei Bo; Lianghao Guo; Yang Yang; Jialu Ma; Kaicheng Wang; Jingchao Tang; Zhe Wu; Baoqing Zeng; Yubin Gong

doi:10.1109/ACCESS.2020.2964780

IEEE Access (Jan 2020)

Numerical Study of Voltage-Gated Ca<sup>2+</sup> Transport Irradiated by Terahertz Electromagnetic Wave

Wenfei Bo,
Lianghao Guo,
Yang Yang,
Jialu Ma,
Kaicheng Wang,
Jingchao Tang,
Zhe Wu,
Baoqing Zeng,
Yubin Gong

Affiliations

Wenfei Bo: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
Lianghao Guo: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
Yang Yang: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
Jialu Ma: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
Kaicheng Wang: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
Jingchao Tang: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
Zhe Wu: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
Baoqing Zeng: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
Yubin Gong: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China

DOI: https://doi.org/10.1109/ACCESS.2020.2964780
Journal volume & issue: Vol. 8
pp. 10305 – 10315

Abstract

Read online

This paper simulates Ca2+ transmembrane transport through voltage-gated Ca2+ channels in response to terahertz electromagnetic irradiation. The active transport of Ca2+ ions is taken into considerations in the Ca2+ transport. Temperature variations due to terahertz electromagnetic loss in physiological medium are simulated. The electromagnetic interaction between terahertz fields and physiological mobile ions at the cellular level is deduced from relativistic electrodynamics. It shows that effects of 0.1 ~ 3 THz electromagnetic fields on cell mobile ions are primarily due to effects of electric fields, and effects of magnetic fields at the cellular level are insignificant. In addition, numerical simulation reveals that terahertz irradiation causes vibration of membrane potential, which is able to activate voltage-gated Ca2+ channels. Besides, bioeffects of terahertz frequency, irradiation duration and electric intensity on the increment of intracellular Ca2+ concentration due to activation of voltage-gated Ca2+ channels are revealed. Meanwhile, numerical results show that temperature rises are inconsequential in the case of different irradiation parameters, indicating the non-thermal bioeffects of voltage-gated Ca2+ transmembrane transport due to terahertz irradiation. Furthermore, the results also reveal that thermal bioeffect can be significant if the irradiation duration is raised long enough for high-dose terahertz irradiation. The numerical simulations lay the basis for understanding the bioeffects of terahertz irradiation on Ca2+ transmembrane transport and pave the way for further exploration in modulation of intracellular Ca2+ concentration with terahertz electromagnetic wave.

Published in IEEE Access

ISSN: 2169-3536 (Online)
Publisher: IEEE
Country of publisher: United States
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering
Website: https://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=6287639

About the journal

Abstract

Keywords