Nature Communications (Oct 2020)
A high-stringency blueprint of the human proteome
- Subash Adhikari,
- Edouard C. Nice,
- Eric W. Deutsch,
- Lydie Lane,
- Gilbert S. Omenn,
- Stephen R. Pennington,
- Young-Ki Paik,
- Christopher M. Overall,
- Fernando J. Corrales,
- Ileana M. Cristea,
- Jennifer E. Van Eyk,
- Mathias Uhlén,
- Cecilia Lindskog,
- Daniel W. Chan,
- Amos Bairoch,
- James C. Waddington,
- Joshua L. Justice,
- Joshua LaBaer,
- Henry Rodriguez,
- Fuchu He,
- Markus Kostrzewa,
- Peipei Ping,
- Rebekah L. Gundry,
- Peter Stewart,
- Sanjeeva Srivastava,
- Sudhir Srivastava,
- Fabio C. S. Nogueira,
- Gilberto B. Domont,
- Yves Vandenbrouck,
- Maggie P. Y. Lam,
- Sara Wennersten,
- Juan Antonio Vizcaino,
- Marc Wilkins,
- Jochen M. Schwenk,
- Emma Lundberg,
- Nuno Bandeira,
- Gyorgy Marko-Varga,
- Susan T. Weintraub,
- Charles Pineau,
- Ulrike Kusebauch,
- Robert L. Moritz,
- Seong Beom Ahn,
- Magnus Palmblad,
- Michael P. Snyder,
- Ruedi Aebersold,
- Mark S. Baker
Affiliations
- Subash Adhikari
- Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University
- Edouard C. Nice
- Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University
- Eric W. Deutsch
- Institute for Systems Biology
- Lydie Lane
- Faculty of Medicine, SIB-Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, University of Geneva, CMU
- Gilbert S. Omenn
- Department of Computational Medicine and Bioinformatics, University of Michigan
- Stephen R. Pennington
- UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin
- Young-Ki Paik
- Yonsei Proteome Research Center
- Christopher M. Overall
- Faculty of Dentistry, University of British Columbia
- Fernando J. Corrales
- Functional Proteomics Laboratory, Centro Nacional de Biotecnología-CSIC, Proteored-ISCIII
- Ileana M. Cristea
- Department of Molecular Biology, Princeton University
- Jennifer E. Van Eyk
- Cedars Sinai Medical Center, Advanced Clinical Biosystems Research Institute, The Smidt Heart Institute
- Mathias Uhlén
- Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology
- Cecilia Lindskog
- Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University
- Daniel W. Chan
- Department of Pathology and Oncology, Johns Hopkins University School of Medicine
- Amos Bairoch
- Faculty of Medicine, SIB-Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, University of Geneva, CMU
- James C. Waddington
- UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin
- Joshua L. Justice
- Department of Molecular Biology, Princeton University
- Joshua LaBaer
- Biodesign Institute, Arizona State University
- Henry Rodriguez
- Office of Cancer Clinical Proteomics Research, National Cancer Institute, NIH
- Fuchu He
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Markus Kostrzewa
- Bruker Daltonik GmbH, Microbiology and Diagnostics
- Peipei Ping
- Cardiac Proteomics and Signaling Laboratory, Department of Physiology, David Geffen School of Medicine, University of California Los Angeles
- Rebekah L. Gundry
- CardiOmics Program, Center for Heart and Vascular Research, Division of Cardiovascular Medicine and Department of Cellular and Integrative Physiology, University of Nebraska Medical Center
- Peter Stewart
- Department of Chemical Pathology, Royal Prince Alfred Hospital
- Sanjeeva Srivastava
- Indian Institute of Technology Bombay
- Sudhir Srivastava
- Cancer Biomarkers Research Branch, National Cancer Institute, National Institutes of Health
- Fabio C. S. Nogueira
- Proteomics Unit and Laboratory of Proteomics, Institute of Chemistry, Federal University of Rio de Janeiro
- Gilberto B. Domont
- Proteomics Unit and Laboratory of Proteomics, Institute of Chemistry, Federal University of Rio de Janeiro
- Yves Vandenbrouck
- University of Grenoble Alpes, Inserm, CEA, IRIG-BGE
- Maggie P. Y. Lam
- Departments of Medicine-Cardiology and Biochemistry and Molecular Genetics, University of Colorado
- Sara Wennersten
- Division of Cardiology, Department of Medicine, University of Colorado
- Juan Antonio Vizcaino
- European Molecular Biology Laboratory, European Bioinformatics Institute
- Marc Wilkins
- School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Jochen M. Schwenk
- Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology
- Emma Lundberg
- Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology
- Nuno Bandeira
- Department of Computer Science and Engineering, University of California, San Diego
- Gyorgy Marko-Varga
- Department of Biomedical Engineering, Lund University
- Susan T. Weintraub
- Department of Biochemistry and Structural Biology, University of Texas Health Science Center San Antonio, UT Health
- Charles Pineau
- University of Rennes, Inserm, EHESP, IREST, UMR_S 1085
- Ulrike Kusebauch
- Institute for Systems Biology
- Robert L. Moritz
- Institute for Systems Biology
- Seong Beom Ahn
- Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University
- Magnus Palmblad
- Leiden University Medical Center
- Michael P. Snyder
- Department of Genetics, Stanford School of Medicine
- Ruedi Aebersold
- Institute for Systems Biology
- Mark S. Baker
- Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University
- DOI
- https://doi.org/10.1038/s41467-020-19045-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
The Human Proteome Project (HPP) was launched in 2010 to enhance accurate annotation of the genome-encoded proteome. Ten years later, the HPP releases its first blueprint of the human proteome, annotating 90% of all known proteins at high-stringency and discussing the implications of proteomics for precision medicine.
