Nature Communications (Aug 2021)
RSPO3 is important for trabecular bone and fracture risk in mice and humans
- Karin H. Nilsson,
- Petra Henning,
- Maha El Shahawy,
- Maria Nethander,
- Thomas Levin Andersen,
- Charlotte Ejersted,
- Jianyao Wu,
- Karin L. Gustafsson,
- Antti Koskela,
- Juha Tuukkanen,
- Pedro P. C. Souza,
- Jan Tuckermann,
- Mattias Lorentzon,
- Linda Engström Ruud,
- Terho Lehtimäki,
- Jon H. Tobias,
- Sirui Zhou,
- Ulf H. Lerner,
- J. Brent Richards,
- Sofia Movérare-Skrtic,
- Claes Ohlsson
Affiliations
- Karin H. Nilsson
- Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg
- Petra Henning
- Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg
- Maha El Shahawy
- Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg
- Maria Nethander
- Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg
- Thomas Levin Andersen
- Department of Clinical Research, University of Southern Denmark
- Charlotte Ejersted
- Department of Endocrinology, Odense University Hospital
- Jianyao Wu
- Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg
- Karin L. Gustafsson
- Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg
- Antti Koskela
- Department of Anatomy and Cell Biology, Faculty of Medicine, Institute of Cancer Research and Translational Medicine, University of Oulu
- Juha Tuukkanen
- Department of Anatomy and Cell Biology, Faculty of Medicine, Institute of Cancer Research and Translational Medicine, University of Oulu
- Pedro P. C. Souza
- Innovation in Biomaterials Laboratory, Faculty of Dentistry, Federal University of Goiás
- Jan Tuckermann
- Institute of Comparative Molecular Endocrinology (CME), University of Ulm
- Mattias Lorentzon
- Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg
- Linda Engström Ruud
- Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories
- Jon H. Tobias
- Musculoskeletal Research Unit, Translational Health Sciences, and Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol
- Sirui Zhou
- Department of Medicine, Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, McGill University
- Ulf H. Lerner
- Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg
- J. Brent Richards
- Department of Medicine, Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, McGill University
- Sofia Movérare-Skrtic
- Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg
- Claes Ohlsson
- Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg
- DOI
- https://doi.org/10.1038/s41467-021-25124-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Genetic association signals for fractures have been reported at the RSPO3 locus, but the causal gene and the underlying mechanism are unknown. Here, the authors show that RSPO3 exerts an important role for vertebral trabecular bone mass and bone strength in mice and fracture risk in humans.
