A DNA dual lock-and-key strategy for cell-subtype-specific siRNA delivery

Kewei Ren; Ying Liu; Jie Wu; Yue Zhang; Jing Zhu; Min Yang; Huangxian Ju

doi:10.1038/ncomms13580

Nature Communications (Nov 2016)

A DNA dual lock-and-key strategy for cell-subtype-specific siRNA delivery

Kewei Ren,
Ying Liu,
Jie Wu,
Yue Zhang,
Jing Zhu,
Min Yang,
Huangxian Ju

Affiliations

Kewei Ren: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University
Ying Liu: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University
Jie Wu: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University
Yue Zhang: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University
Jing Zhu: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University
Min Yang: Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, University College London
Huangxian Ju: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University

DOI: https://doi.org/10.1038/ncomms13580
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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Delivery of siRNA to target cells is essential for in vivogene therapy. Here the authors demonstrate an oligonucleotide aptamer that targets therapeutic siRNA to a specific cell type.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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