Tumor‐targeted nano‐adjuvants to synergize photomediated immunotherapy enhanced antitumor immunity
Hongda Zhu,
Chaobo Yang,
Aqin Yan,
Wei Qiang,
Rui Ruan,
Kai Ma,
Yeneng Guan,
Jing Li,
Qi Yu,
Hongmei Zheng,
Le Tu,
Shuang Liu,
Zhu Dai,
Yao Sun
Affiliations
Hongda Zhu
Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province)Key Laboratory of Fermentation Engineering (Ministry of Education)National “111” Center for Cellular Regulation and Molecular PharmaceuticsSchool of Food and Biological EngineeringHubei University of Technology WuhanChina
Chaobo Yang
Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province)Key Laboratory of Fermentation Engineering (Ministry of Education)National “111” Center for Cellular Regulation and Molecular PharmaceuticsSchool of Food and Biological EngineeringHubei University of Technology WuhanChina
Aqin Yan
Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province)Key Laboratory of Fermentation Engineering (Ministry of Education)National “111” Center for Cellular Regulation and Molecular PharmaceuticsSchool of Food and Biological EngineeringHubei University of Technology WuhanChina
Wei Qiang
Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province)Key Laboratory of Fermentation Engineering (Ministry of Education)National “111” Center for Cellular Regulation and Molecular PharmaceuticsSchool of Food and Biological EngineeringHubei University of Technology WuhanChina
Rui Ruan
Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province)Key Laboratory of Fermentation Engineering (Ministry of Education)National “111” Center for Cellular Regulation and Molecular PharmaceuticsSchool of Food and Biological EngineeringHubei University of Technology WuhanChina
Kai Ma
Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province)Key Laboratory of Fermentation Engineering (Ministry of Education)National “111” Center for Cellular Regulation and Molecular PharmaceuticsSchool of Food and Biological EngineeringHubei University of Technology WuhanChina
Yeneng Guan
Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province)Key Laboratory of Fermentation Engineering (Ministry of Education)National “111” Center for Cellular Regulation and Molecular PharmaceuticsSchool of Food and Biological EngineeringHubei University of Technology WuhanChina
Jing Li
Hubei Cancer HospitalTongji Medical CollegeHuazhong University of Science and Technology WuhanChina
Qi Yu
Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province)Key Laboratory of Fermentation Engineering (Ministry of Education)National “111” Center for Cellular Regulation and Molecular PharmaceuticsSchool of Food and Biological EngineeringHubei University of Technology WuhanChina
Hongmei Zheng
Hubei Cancer HospitalTongji Medical CollegeHuazhong University of Science and Technology WuhanChina
Le Tu
Key Laboratory of Pesticide and Chemical BiologyMinistry of EducationCollege of ChemistryCentral China Normal University WuhanChina
Shuang Liu
School of Materials Science and EngineeringWuhan University of Technology WuhanChina
Zhu Dai
Hubei Cancer HospitalTongji Medical CollegeHuazhong University of Science and Technology WuhanChina
Yao Sun
Key Laboratory of Pesticide and Chemical BiologyMinistry of EducationCollege of ChemistryCentral China Normal University WuhanChina
Abstract Photomediated immunotherapy explored to combine the anti‐cancer effect of phototherapy with the immune enhancement ability of immunotherapy, and shown great prospects for cancer treatment strategies. However, photomediated immunotherapy triggered antitumor immunity through the release of tumor antigens and damage‐associated molecular patterns from necrotic tumor cells was not enough mighty to improve the therapeutic benefits due to the immunosuppressive tumor microenvironments. Herein, a tumor‐targeted nano‐adjuvant Fucoidan@Al(OH)3‐Poly(I:C)/IR‐820 for tumor‐targeted therapy and metastasis inhibition was designed and prepared. The intrinsic immunomodulatory effects of tumor‐targeted nano‐adjuvant and their ability to simultaneously trigger tumor antigen release, thereby reversing immunosuppression and achieving potent antitumor immunity and augmented cancer therapy, were explored. The results proved that the multifunctional nano‐adjuvant combined with photothermal, photodynamic, and immunotherapy could effectively treat breast cancer and had metastasis inhibition effect by enhancing anti‐tumor immunity through immunomodulation, it should have great application potential in the treatment of breast cancer.