Nature Communications (Nov 2020)
Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells
- LiangYu Zhao,
- ChenCheng Yao,
- XiaoYu Xing,
- Tao Jing,
- Peng Li,
- ZiJue Zhu,
- Chao Yang,
- Jing Zhai,
- RuHui Tian,
- HuiXing Chen,
- JiaQiang Luo,
- NaChuan Liu,
- ZhiWen Deng,
- XiaoHan Lin,
- Na Li,
- Jing Fang,
- Jie Sun,
- ChenChen Wang,
- Zhi Zhou,
- Zheng Li
Affiliations
- LiangYu Zhao
- Department of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- ChenCheng Yao
- Department of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- XiaoYu Xing
- Department of Urology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
- Tao Jing
- Department of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Peng Li
- Department of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- ZiJue Zhu
- Department of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Chao Yang
- Department of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Jing Zhai
- Department of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- RuHui Tian
- Department of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- HuiXing Chen
- Department of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- JiaQiang Luo
- Department of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- NaChuan Liu
- Department of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- ZhiWen Deng
- School of Life Science and Technology, ShanghaiTech University
- XiaoHan Lin
- School of Life Science and Technology, ShanghaiTech University
- Na Li
- School of Life Science and Technology, ShanghaiTech University
- Jing Fang
- School of Life Science and Technology, ShanghaiTech University
- Jie Sun
- Department of Urology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
- ChenChen Wang
- Shanghai Advanced Research Institute, Stem Cell and Reproductive Biology Laboratory, Chinese Academy of Sciences
- Zhi Zhou
- School of Life Science and Technology, ShanghaiTech University
- Zheng Li
- Department of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-19414-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Non-obstructive azoospermia affects 1% of men. Here, authors perform single-cell transcriptomic analysis of human testicular cells from healthy donors and non-obstructive azoospermia patients and find that inhibition of Wnt signaling promotes the maturation of Sertoli cells from patients.
