Current status and future prospects for enabling chemistry technology in the drug discovery process [version 1; referees: 2 approved]

Abstract

This review covers recent advances in the implementation of enabling chemistry technologies into the drug discovery process. Areas covered include parallel synthesis chemistry, high-throughput experimentation, automated synthesis and purification methods, flow chemistry methodology including photochemistry, electrochemistry, and the handling of “dangerous” reagents. Also featured are advances in the “computer-assisted drug design” area and the expanding application of novel mass spectrometry-based techniques to a wide range of drug discovery activities.

Keywords

• Biomacromolecule-Ligand Interactions
• Cell Signaling & Trafficking Structures
• Drug Discovery & Design
• Experimental Biophysical Methods
• Macromolecular Assemblies & Machines
• Membrane Proteins & Energy Transduction
• Pharmacokinetics & Drug Delivery
• Protein Folding
• Small Molecule Chemistry
• Theory & Simulation