Pharmacological potential of micheliolide: A focus on anti-inflammatory and anticancer activities
Jalal Uddin,
Mehwish Fatima,
Ammara Riaz,
Ghulam Mustafa Kamal,
Abdullatif Bin Muhsinah,
Abdul Razzaq Ahmed,
Ramsha Iftikhar
Affiliations
Jalal Uddin
Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Asir, 61421, Saudi Arabia; Corresponding author.
Mehwish Fatima
Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000, Pakistan
Ammara Riaz
Department of Life Sciences, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan, 64200, Pakistan
Ghulam Mustafa Kamal
Institute of Chemistry, Khwaja Fareed University of Engineering & Information Technology, Rahim Yar Khan, 64200, Pakistan; Corresponding author. Institute of Chemistry, Faculty of Natural and Applied Sciences, Khwaja Fareed University of Engineering and Information Technology, University, Rahim Yar Khan, 64200, Pakistan.
Abdullatif Bin Muhsinah
Department of Pharmacognosy, College of Pharmacy, King Khalid University, Asir, 61421, Saudi Arabia
Abdul Razzaq Ahmed
Department of Prosthodontics, College of Dentistry, King Khalid University, Abha, 61421, Saudi Arabia
Ramsha Iftikhar
School of Chemistry, University of New South Wales, 2033, Sydney, Australia
Micheliolide (MCL) is a chief constituent of plants such as Magnolia grandiflora L., Michelia compressa (Maxim.) Sarg. and Michelia champaca L. It is known to exhibit significant anticancer activity by various scientific investigations. This review aims to emphasize the anticancer and antiinflammatory activities of MCL. In this review, we summarized the published data in peer-reviewed manuscripts published in English. Our search was based on the following scientific search engines and databases: Scopus, Google Scholar, ScienceDirect, Springer, PubMed, and SciFinder, MCL possesses a broad spectrum of medicinal properties like other sesquiterpene lactones. The anticancer activity of this compound may be attributed to the modulation of several signaling cascades (PI3K/Akt and NF-κB pathways). It also induces apoptosis by arresting the cell cycle at the G1/G0 phase, S phase, and G2/M phase in many cancer cell lines. Very little data is available on its modulatory action on other signaling cascades like MAPK, STAT3, Wnt, TGFβ, Notch, EGFR, etc. This compound can be potentiated as a novel anticancer drug after thorough investigations in vitro, in vivo, and in silico-based studies.
